Accutane (Acne Care) 10mg/50tabs - Isotretinoin - Innovagen

• Classification: Dermatotropic drug
• Standard: Retinoic acid derivative
• Hepatotoxicity: Mild
• Active Half-life: 22 hours
• Recommended Dosage: 10-40 mg/day

Accutane is a pharmaceutical-grade Isotretinoin. FDA approves isotretinoin, and it has been considered the most effective treatment for severe acne worldwide for more than four decades.

Accutane Clinical Trials

2005

Study Type: Clinical Trial

Actual Enrollment: 135 patients

Sexes Eligible for Trial: Men and Women

Intervention Model: Parallel Assignment

Primary Purpose: Treatment of severe acne (acne vulgaris)

Experimental Group

Patients received 1 mg/kg of body weight (100 mg/day for 220lb patient) per day of Accutane for 2-28 weeks.

Results: 127 patients noticed complete clearance of acne

Accutane Success Ratio: 95%

Acne General Info

Acne (acne vulgaris) is a condition that occurs when oil from sebaceous glands and dead skin cells clog the hair follicles. The face, chest, shoulders, and back are affected the most because of the high concentration of sebaceous glands (oil glands).

It was demonstrated that androgens and genetics (80% of cases) are the primary causes of severe acne. Severe acne is the eighth most common disease on the planet. 

Accutane Pharmacokinetics

Isotretinoin has a similar chemical structure with retinoic acid and Vitamin A (retinol). It successfully inhibits the sebaceous gland functioning, which results in lower oil production in the skin and no acne development. 

Accutane in Bodybuilding

Androgens and genetic predisposition (80% of cases) are the leading causes of acne. It was demonstrated that Androgens stimulate the sebaceous glands to secrete more sebum (oil). Also, it was noted that androgens not only make sebaceous glands hyperactive, they also increase the size of sebaceous glands over time.

Acne is one of the most common temporary side effects associated with steroid use. Athletes and bodybuilders widely use Accutane for steroid-induced acne. Accutane is considered the only effective drug that is capable of treating severe acne caused by AAS administration.